Repressor/activator protein 1 (RAP1) is a highly evolutionary conserved protein found at telomeres. Here we demonstrate that RAP1 is required to protect telomeres specifically in replicative senescent

NIAID Data Ecosystem10

The Effect of Pro-Inflammatory Conditioning and/or High Glucose on Telomere Shortening of Aging Fibroblasts

细胞衰老机制

端粒生物学

Cardiovascular disease and diabetes have been linked to shorter telomeres, but it is not yet clear which risk factors contribute to shorter telomeres in patients. Our aim was to examine whether pro-in

NIAID Data Ecosystem20

Knock-down of U2AF2 in human foreskin fibroblasts

基因功能敲降

细胞衰老机制

Knock-down of U2AF2 leds to cell senescene and activates intronic poly(A) sites. Control data of HFF cells are publicly available at PRJNA565612.

NIAID Data Ecosystem10