Transcriptome analysis revealed potential neuro-immune interaction in papillary thyroid carcinoma tissues

We aimed to explore the potential interaction between neural markers and signatures of tumor microenvironment. Comparative gene expression profiling analysis of Gene set variation analysis (GSVA) was conducted to calculate the enrichment scores of gene sets regarding tumor-infiltrating immune cells and tumor microenvironment. Overall design: We then performed mRNA sequencing was conducted using 6 pairs of PTC and adjacent normal tissues.