Meta-, Regioselective Amination of Cyclic Diaryliodoniums through C–I and C–O Bond Cleavages: An Access to Functionalized Coumarins

Despite the widespread ortho-functionalization of cyclic diaryliodoniums in organic chemistry, the corresponding meta-functionalization is less explored. Herein, we report a practical meta-selective activation of cyclic hypervalent iodoniums for the synthesis of 4-amino coumarin derivatives in a broad functional group tolerance and environmentally friendly manner. The practicability of this protocol was further highlighted by the late-stage modification of some common pharmaceuticals and natural products.