Supplementary Table 1 from Genomic and Transcriptomic Landscape of an Oral Squamous Cell Carcinoma Mouse Model for Immunotherapy

NIAID Data Ecosystem2026-05-01 收录

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https://figshare.com/articles/dataset/Supplementary_Table_1_from_Genomic_and_Transcriptomic_Landscape_of_an_Oral_Squamous_Cell_Carcinoma_Mouse_Model_for_Immunotherapy/30721128 数据链接链接失效反馈

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资源简介：

detailed data of WES

创建时间：

2023-11-01

Targeted sequencing of IDH1 and IDH2 genes was performed using bone marrow specimens from matched diagnosis and relapsed AML patients with IDH baseline mutation before or after IDHmut inhibitor treatment. gDNA was extracted from the bone marrow clot sections using the QuickExtract FFPE DNA extraction kit (Epicenter Biotechnologies) following the manufacturer's instructions. The exon sequences of IDH1 and IDH2 genes were PCR amplified. The DNA fragments for each exon were purified with QIAquick spin columns (Qiagen), mixed at equal molarity, and fragmented using Covaris acoustic shearing following the manufacturer’s instructions. Sonicated DNA was processed for library generation using NEBNext Ultra II DNA Kits (New England Biolabs) following the manufacturer’s protocol. Libraries with different index sequences were quantified, pooled, and sequenced on an Illumina Nextseq500 system using the 75bp high output sequencing kit.. Targeted sequencing of IDH1 and IDH2 genes in AML samples

AMLIDH突变耐药机制

肿瘤治疗基因组学

Acquired resistance to allosteric inhibition of cancer-associated IDH mutations has been described through mutations to restore the production of oncometabolite R-2HG, yet the complete repertoire of I

NIAID Data Ecosystem30

Genomic resistance patterns to second generation androgen blockade in paired tumor biopsies of metastatic castrate-resistant prostate cancer

耐药性前列腺癌

肿瘤治疗基因组学

We examined genetic resistance to second generation androgen targeting therapies (abiraterone acetate or enzalutamide) by analyzing whole exome sequencing of patient-matched pre-treatment and post-res

NIAID Data Ecosystem20

37eb9c49-071e-4c28-a721-31bf8408e627 - samples

肿瘤治疗基因组学

外显子测序

Whole Exome Sequencing Data for 10 patients for treatment with the ICI NivolumabEGA dataset EGAD00001011117

NIAID Data Ecosystem20

MysiRNA-Designer: A Workflow for Efficient siRNA Design

RNA设计

肿瘤治疗基因组学

The design of small interfering RNA (siRNA) is a multi factorial problem that has gained the attention of many researchers in the area of therapeutic and functional genomics. MysiRNA score was previou

NIAID Data Ecosystem20

Additional file 19: of A systematic analysis of genomics-based modeling approaches for prediction of drug response to cytotoxic chemotherapies

药物反应预测

肿瘤治疗基因组学

MAD values for NLSVR CTR2 models discussed in section E. (XLSX 26 kb)

Figshare2019-06-17 更新20