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Asymmetric Synthesis of Cyclopenta­[3,4]­pyrrolo­indolones <i>via N</i>-Heterocyclic Carbene-Catalyzed Michael/Aldol/Lactamization Cascade Reaction

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The N-heterocyclic carbene-catalyzed asymmetric Michael/aldol/lactamization cascade reaction of enals and indole-derived enones for the synthesis of functionalized cyclopenta­[3,4]­pyrrolo­indolones with four consecutive stereogenic centers has been achieved. The products were obtained in good yield with high diastereoselectivity and excellent enantioselectivity.

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2017-06-02
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