NLRP3 Cys126 palmitoylation by ZDHHC7 Promotes Inflammasome Activation

In the manuscript, we show that NLRP3 is palmitoylated on Cys126 by ZDHHC7. This palmitoylation promotes the trans Golgi network localization of NLRP3 during and after the activation process, which promotes the interaction with ASC and eventually the downstream inflammasome activation. The data here contain western blot images and confocal microscopy images that support the conclusions.本文研究表明，ZDHHC7可在NLRP3的第126位半胱氨酸残基（Cys126）处对其进行棕榈酰化修饰。该棕榈酰化修饰可在NLRP3激活过程中及激活后，促进其在反式高尔基网络的定位，进而增强其与ASC的相互作用，最终触发下游炎症小体的激活。本数据集包含支撑上述研究结论的蛋白质免疫印迹（Western blot）图像与共聚焦显微镜图像。