Human MTHFD2 in complex with Compound 1

Human MTHFD2 in complex with Compound 1 Descriptor: 5-(4-oxo-2-phenyl-1,5,7,8-tetrahydropyrido[4,3-d]pyrimidine-6(4H)-carbonyl)-1,3-dihydro-2H-2lambda~6~,1-benzothiazole-2,2-dione, Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, ... Authors: Suzuki, M, Matsui, Y, Matsuhashi, N, Kawai, J. Deposit date: 2019-02-20 Release date: 2019-06-05 Last modified: 2023-11-22 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Structure-Based Design and Synthesis of an Isozyme-Selective MTHFD2 Inhibitor with a Tricyclic Coumarin Scaffold. Acs Med.Chem.Lett., 10, 2019与化合物1结合的人类MTHFD2复合物 描述符：5-(4-氧代-2-苯基-1,5,7,8-四氢吡啶并[4,3-d]嘧啶-6(4H)-羰基)-1,3-二氢-2H-2λ⁶,1-苯并噻唑-2,2-二酮；双功能亚甲基四氢叶酸脱氢酶/环水解酶，线粒体型，…… 作者：Suzuki M、Matsui Y、Matsuhashi N、Kawai J 提交日期：2019-02-20 发布日期：2019-06-05 最后修改日期：2023-11-22 检测方法：X射线衍射（2.5 Å） 引用文献：《基于结构设计与合成具有三环香豆素骨架的MTHFD2同工酶选择性抑制剂》，Acs Med.Chem.Lett., 10, 2019