Sympathetic neuropathy of the bone marrow haematopoietic stem cell niche is essential for myeloproliferative neoplasms

ChEBI2014-03-12 更新2026-07-21 收录

骨髓增殖性肿瘤病理机制

造血干细胞微环境神经调控

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-55801 数据链接链接失效反馈

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Sympathetic neuropathy of the bone marrow haematopoietic stem cell niche is essential for myeloproliferative neoplasms

创建时间：

2014-03-12

STAT1 is essential for hematopoietic stem cell function and maintains a MHC IIhi stem cell subset that resists myeloablation and neoplastic expansion. STAT1 is essential for hematopoietic stem cell function and maintains a MHC IIhi stem cell subset that resists myeloablation and neoplastic expansion

干细胞稳态调控

骨髓增殖性肿瘤病理机制

Adult hematopoietic stem cells (HSCs) are predominantly quiescent and can be activated in response to acute stress such as infection or cytotoxic insults. STAT1 is a pivotal mediator of interferon (IF

NIAID Data Ecosystem50

HiJAKing the hematopoietic system: a low-frequency JAK2V617F clone drives myeloproliferative neoplasm pathology

骨髓增殖性肿瘤病理机制

JAK2V617F突变研究

JAK2V617F is one of the most common mutations in clonal hematopoiesis of indeterminate potential (CHIP) and a major driver of myeloproliferative neoplasms (MPN). To determine the impact of the low fre

NIAID Data Ecosystem40

Loss of cohesin in vivo alters adult stem cell homeostasis leading to myeloproliferative neoplasms

干细胞稳态调控

骨髓增殖性肿瘤病理机制

Loss of cohesin in vivo alters adult stem cell homeostasis leading to myeloproliferative neoplasms

ChEBI2015-09-16 更新20

Cancer-associated rs6983267 SNP and its accompanying long non-coding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Cancer-associated rs6983267 SNP and its accompanying long non-coding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations

骨髓增殖性肿瘤病理机制

SNP单核苷酸多态性

The cancer-risk associated rs6983267 single nucleotide polymorphism (SNP) and the accompanying long non-coding RNA CCAT2 in the highly amplified 8q24.21 region has been implicated in cancer predisposi

NIAID Data Ecosystem40

Integrated genomic analysis illustrates the central role of JAK-STAT pathway activation in myeloproliferative neoplasm pathogenesis [HEL cell lines]. Homo sapiens

骨髓增殖性肿瘤病理机制

JAK-STAT信号通路

We used expression profiling, SNP arrays, and mutational profiling to investigate a well-characterized cohort of MPN patients. MPN patients with homozygous JAK2V617F mutations were characterized by a

NIAID Data Ecosystem30

Sympathetic neuropathy of the bone marrow haematopoietic stem cell niche is essential for myeloproliferative neoplasms

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