Hyperexcitable arousal circuits cause sleep instability during aging

NIAID Data Ecosystem2026-03-12 收录

催眠神经机制

神经元衰老机制

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE160581 数据链接链接失效反馈

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资源简介：

10X single nucleus RNAseq of hyprcretin neurons from lateral hypothalamus in young and aged mice single cell analysis of young and aged hcrt neurons in male and female mice

创建时间：

2021-05-01

MOESM4 of The Bdnf and Npas4 genes are targets of HDAC3-mediated transcriptional repression

表观遗传调控

神经元衰老机制

Additional file 4: Table S4. DEGs having HDAC3 peaks in promoter region. Previously published data [77] of differentially-expressed genes during neuronal death was utilized and overlapping analysis wi

NIAID Data Ecosystem110

Data_Sheet_1_DNA Methyltransferase 1 (DNMT1) Function Is Implicated in the Age-Related Loss of Cortical Interneurons.DOCX

神经元衰老机制

表观遗传调控

Increased life expectancy in modern society comes at the cost of age-associated disabilities and diseases. Aged brains not only show reduced excitability and plasticity, but also a decline in inhibiti

NIAID Data Ecosystem30

Cell type and age-dependent effects of Brap loss of function on cerebral cortical gene expression

基因功能缺失分析

神经元衰老机制

To determine the impact of Brap loss of function on cellular senescence in cerebral cortex, we performed gene expression profiling analysis of mice with Brap conditional deletions in neural progenitor

NIAID Data Ecosystem20

CD8+ T cells induce interferon-responsive oligodendrocytes during white matter aging. CD8+ T cells induce interferon-responsive oligodendrocytes during white matter aging

神经元衰老机制

白质病理单细胞分析

A hallmark of nervous system aging is a decline of white matter volume and function, but the underlying mechanisms leading to white matter pathology are unknown. Here, we found age-related alterations

NIAID Data Ecosystem40

Phosphorylation of the GluN2B C-tail at S1303 by CaMKII or DAPK1: no indication for involvement in neuronal mechanisms related to ischemia or LTP

NMDA受体

神经元衰老机制

Binding of the Ca2+/calmodulin-dependent protein kinase II (CaMKII) and the death associated protein kinase 1 (DAPK1) to the NMDA-type glutamate receptor (NMDAR) subunit GluN2B near S1303 have been im

NIAID Data Ecosystem20

Hyperexcitable arousal circuits cause sleep instability during aging

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