Effects of novel selective androgen receptor modulator, TEI-SARM2, on gene expression profile changes in skeletal muscle

TEI-SARM2 is a novel selective androgen receptor modulator. To assess the effects of TEI-SARM2 on skeletal muscle, we generated myofiber specific ARKO using HSA-Cre and AR flox mice (mARKO). Male mARKO and littermate control (ARL2/Y) mice underwent ORX or not. Nine days after ORX, the mice were treated with TEI-SARM2 (10 mg/kg weekly, p.o.) or vehicle (weekly, p.o.) for another 2 weeks. After euthanasia, the bulbocavernosus (BC) muscles were collected and total RNA was extracted. mRNA profiles of bulbocavernosus (BC) muscles obtained from control and mARKO mice treated with 1) sham operation, 2) ORX and vehicle administration or 3) ORX and TEI-SARM2 administration, were generated by sequencing using Illumina Myseq separately for control and mARKO.