CRYSTAL STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 3-[(CYCLOPROPYLMETHYL)AMINO] -N-(4-PHENYLPYRIDIN-3-YL)IMIDAZO[1,2-B]PYRIDAZINE-8-CARBOX AMIDE

CRYSTAL STRUCTURE OF GLYCOGEN SYNTHASE KINASE 3 BETA COMPLEXED WITH 3-[(CYCLOPROPYLMETHYL)AMINO] -N-(4-PHENYLPYRIDIN-3-YL)IMIDAZO[1,2-B]PYRIDAZINE-8-CARBOX AMIDE Descriptor: (4S)-3-[(cyclopropylmethyl)amino]-N-(4-phenylpyridin-3-yl)imidazo[1,2-b]pyridazine-8-carboxamide, Glycogen synthase kinase-3 beta Authors: Lewis, H.A, Muckelbauer, J.K. Deposit date: 2022-06-30 Release date: 2023-03-22 Last modified: 2024-05-22 Method: X-RAY DIFFRACTION (2.374 Å) Cite: Design, Structure-Activity Relationships, and In Vivo Evaluation of Potent and Brain-Penetrant Imidazo[1,2- b ]pyridazines as Glycogen Synthase Kinase-3 beta (GSK-3 beta ) Inhibitors. J.Med.Chem., 66, 2023糖原合成酶激酶3β（Glycogen synthase kinase 3 beta, GSK-3β）与3-[(环丙基甲基)氨基]-N-(4-苯基吡啶-3-基)咪唑并[1,2-b]哒嗪-8-甲酰胺共晶结构 Descriptor: (4S)-3-[(环丙基甲基)氨基]-N-(4-苯基吡啶-3-基)咪唑并[1,2-b]哒嗪-8-甲酰胺，糖原合成酶激酶3β Authors: Lewis, H.A.、Muckelbauer, J.K. Deposit date: 2022年6月30日 Release date: 2023年3月22日 Last modified: 2024年5月22日 Method: X射线衍射（2.374 Å） Cite: 《强效且可透过血脑屏障的咪唑并[1,2-b]哒嗪类糖原合成酶激酶3β（GSK-3β）抑制剂的设计、构效关系及体内评价》，《Journal of Medicinal Chemistry》（J.Med.Chem.），2023年，第66卷