CASA

CASA provides a convenient computing platform for studies of AS in COVID-19 and COVID-19-related infectious diseases. CASA displays microbe-induced alterations of the host cell splicing landscape across different virus families and helps users identify condition-specific splicing patterns, as well as their potential regulators. CASA may greatly facilitate the exploration of AS profiles and novel mechanisms of host cell splicing by viral manipulation.

CASA为新型冠状病毒肺炎（Corona Virus Disease 2019，COVID-19）及新冠相关传染病的可变剪接（Alternative Splicing，AS）研究提供了便捷的计算平台。该平台可展示不同病毒家族中微生物诱导的宿主细胞剪接组景观变化，帮助研究者识别条件特异性剪接模式及其潜在调控因子。CASA可极大推动病毒调控宿主细胞剪接的相关可变剪接谱与新型机制的探索工作。

搜集汇总

背景与挑战

背景概述

CASA是一个计算平台，专为研究COVID-19及相关传染病的可变剪接（AS）设计。它能够展示不同病毒家族引起的宿主细胞剪接变化，帮助用户识别特定条件下的剪接模式及其潜在调控因子，从而促进对剪接谱和病毒操控机制的分析。