The origin and possible functions of local three-stranded DNA-RNA hybrid regions in the mammalian genome is still a matter of discussion. R-loops have been so far essentially detected by immunodetecti
Fig A, Representative experiment of DRIVE Assay in RNaseH1 pretreated (black bars) and not pretreated (white bars) samples. (Panel A) Three positive (RPL13A, BTBD19, MYADM) and two negative (SNRPN, a-
The R package nucleR was used to first smooth DRIP-seq signal using filterFFT function (pcKeepComp = 0.05) and then to extract peaks using peakDetection (threshold = 95%). Finally, overlapping peaks w