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Leucine zipper-based sorting system enables generation of multi-functional CAR T cells

NIAID Data Ecosystem2026-05-02 收录

CAR-NKT细胞疗法

基因整合位点分析

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP477971 数据链接链接失效反馈

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Comparing integration site distribution in dual versus single transduced samples.

应用场景：

创建时间：

2024-07-01

CAR-NKT细胞疗法

T细胞生物学

CD19-specific CARs that comprise CD28 and CD3z signaling domains program highly performing effector functions that mediate potent tumor elimination, but they impart a relatively limited T cell lifespa

干细胞与再生医学数据中心2022-02-20 更新160

TLA sequencing for CamiCre mice

转基因小鼠模型

基因整合位点分析

The CamiCre, one of the widely used CamK2a-Cre mouse lines, has shown abnormalities on the molecular level when compared to wild-type controls. We performed the TLA analysis in order to: 1- Study the

NIAID Data Ecosystem60

IFNg is Critical for CAR T Cell Mediated Myeloid Activation and Induction of Endogenous Immunity. IFNg is Critical for CAR T Cell Mediated Myeloid Activation and Induction of Endogenous Immunity

CAR-NKT细胞疗法

肿瘤免疫微环境

Chimeric antigen receptor (CAR) T cells mediate potent antigen-specific antitumor activity, however, their indirect effects on the endogenous immune system is not well characterized. Remarkably, we de

NIAID Data Ecosystem30

Table_1_CAR T-Cell Therapy: Is CD28-CAR Heterodimerization Its Achilles’ Heel?.xlsx

CAR-NKT细胞疗法

CD28-CAR异二聚化研究

The full text of this article can be freely accessed on the publisher's website.

NIAID Data Ecosystem80

CAR T cells targeting uPAR are effective senolytics

CAR-NKT细胞疗法

衰老细胞清除

Cellular senescence is a stress-response program characterized by stable cell cycle arrest and a secretory program that modulates the tissue microenvironment. Physiologically, senescence serves as a

NIAID Data Ecosystem60

Leucine zipper-based sorting system enables generation of multi-functional CAR T cells

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