Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells

ChEBI2010-03-23 更新2026-07-21 收录

白血病发病机制

髓系细胞信号通路

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Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells

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2010-03-23

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia (RNA-seq of KLF6 KO)

造血干细胞表观遗传学

白血病发病机制

Aging is associated with functional decline of hematopoietic stem cells (HSC) as well as an increased risk of myeloid malignancies. We performed an integrative characterization of epigenomic and trans

NIAID Data Ecosystem50

Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation [scRNA-seq]. Impaired proteolysis of non-canonical RAS proteins drives clonal hematopoietic transformation [scRNA-seq]

白血病发病机制

RAS蛋白降解异常

Recently, screens for mediators of resistance to FLT3 and ABL kinase inhibitors in leukemia resulted in the discovery of LZTR1 as an adaptor of a Cullin-3 RING E3 ubiquitin ligase complex responsible

NIAID Data Ecosystem40

Transcriptional profiling (SMARTer-Seq) has been performed on CD48-/CD48+ LSK hematopoietic cells to determine the effect introduced by the abrogation of Sbds within mesenchymal cells.

白血病发病机制

间质-造血细胞互作

Mesenchymal niche cells may drive tissue failure and malignant transformation in the hematopoietic system but the molecular mechanisms and their relevance to human disease remain poorly defined Here,

NIAID Data Ecosystem30

Gene expression profiling of CA10 and NHD13 murine AML

急性髓系白血病基因表达谱

白血病发病机制

We have compared the gene expression profiles of leukemic tissues in two different mouse models of AML, CALM-AF10 and NHD13, to clincally healthy transgenic and wildtype hematopoetic tissue to identif

Alliance of Genome Resources50

Functional Characterization of Cooperating MGA Mutations in RUNX1::RUNX1T1 Acute Myeloid Leukemia [ATAC-seq]

白血病发病机制

表观遗传调控

MGA (Max-gene associated) is a dual-specificity transcription factor that negatively regulates MYC-target genes to inhibit proliferation and promote differentiation. Loss-of-function mutations in MGA

NIAID Data Ecosystem30

Activation or maintenance of a leukemia stem cell self-renewal pathway in downstream myeloid cells

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