Gene expression in self-activating CAR-T cells with CD28 or 4-1BB costimulatory domains.. Gene expression in self-activating CAR-T cells with CD28 or 4-1BB costimulatory domains.
收藏NIAID Data Ecosystem2026-05-01 收录
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资源简介：
We observed self-activation of SKM-CAR-T cells which target novel mesothelioma antigen. CAR-T with CD28 costimulatory domain showed signs of exhaustion while those with 4-1BB costimulatory domain did not. Changes in the gene expression by substituting CD28 co-stimulatory domain to 4-1BB co-stimulatory domain was investigated. Overall design: We performed RNA-seq analysis of SKM-CAR-T cells with CD28 or 4-1BB together with T cells without transducing CAR.
创建时间：
2023-05-01
