Structure and function based design of Plasmodium-selective proteasome inhibitors

NIAID Data Ecosystem2026-05-02 收录

抗疟药物设计

蛋白酶体抑制剂

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资源简介：

Structure and function based design of Plasmodium-selective proteasome inhibitors

创建时间：

2024-11-13

TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors

蛋白酶体抑制剂

化学结构分析

TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors Descriptor: BENZYL [12-(2-AMINO-2-OXOETHYL)-4-NITRO-10,13-DIOXO-15-[(PROPYLAMINO)CARBONYL]-2-OXA-11,14-DIAZATRICYCLO[15 .2.2.1~3

Protein Data Bank Japan2023-08-30 更新80

New Iron Twist to ChloroquineUpgrading Antimalarials with Immunomodulatory and Antimicrobial Features

抗疟药物设计

多靶点药物化学

Herein, upgraded chloroquine (CQ) derivatives capable of overcoming Plasmodium resistance and, at the same time, suppressing excessive immune response and risk of concurrent bacteremia were developed.

Figshare2023-01-20 更新30

Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide

抗疟药物设计

蛋白质晶体结构解析

Crystal structure of Plasmodium falciparum aminopeptidase N in complex with (S)-2-(3-(2-chlorobenzyl)ureido)-N-hydroxy-4-methylpentanamide Descriptor: (2S)-2-[(2-chlorophenyl)methylcarbamoylamino]-4-m

Protein Data Bank Japan2023-11-22 更新10

Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 14

蛋白酶体抑制剂

蛋白质-配体复合物结构

Yeast 20S proteasome with human beta5i (1-138) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 14 Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION,

Protein Data Bank Japan2024-11-20 更新40

Yeast 20S proteasome mutant: beta5_T3M in complex with ONX0914

蛋白酶体抑制剂

结构生物学

Yeast 20S proteasome mutant: beta5_T3M in complex with ONX0914

NIAID Data Ecosystem20