Whole-genome sequencing analysis of drug resistance genotype phenotype concordance in clinical isolates of Mycobacterium tuberculosis

We performed whole-genome sequencing of 90 clinical isolates of Mycobacterium tuberculosis from Mexico, predominantly drug-resistant, to assess the concordance between resistance-associated genetic variants and phenotypic drug susceptibility testing (DST) results for first- and second-line anti-tuberculosis drugs obtained prior to the implementation of the BPaLM treatment regimen