eccDNAdb

eccDNAdb is a database of extrachromosomal circular DNA profiles in human cancers, and it aims to acquire known and novel extrachromosomal circular DNAs (eccDNAs) in cancers by computational analysis of whole-genome sequencing data. It currently includes 1270 eccDNAs, which were identified in 480 samples (of 42 cancers) after analyzing a total number of 3395 tumor samples (of 57 cancers) including patient tissues, patient-derived xenografts, and cancer cell lines. A total number of 54,901 eccDNA genes were annotated and included in the database as well. With the integration of gene expression, clinical information and chromatin accessibility data, eccDNAdb enables users to easily determine the biological function and clinical relevance of eccDNAs in human cancers.

eccDNAdb是一款收录人类癌症染色体外环状DNA（extrachromosomal circular DNA，eccDNA）图谱的专业数据库，其核心目标为通过全基因组测序数据的计算分析，挖掘癌症中已知及新型染色体外环状DNA（eccDNA）。目前该数据库共收录1270条eccDNA，这些序列是在对总计3395例涵盖57种癌症类型的肿瘤样本（包括患者组织、患者来源异种移植物（patient-derived xenografts）以及癌细胞系）开展分析后，从480例对应42种癌症的样本中鉴定得到的。此外，数据库还注释并收录了共计54901个eccDNA相关基因。通过整合基因表达、临床信息及染色质可及性数据，eccDNAdb可助力用户便捷地探究eccDNA在人类癌症中的生物学功能与临床相关性。

搜集汇总

背景与挑战

背景概述

eccDNAdb是一个人类癌症染色体外环状DNA（eccDNA）数据库，通过分析全基因组测序数据，收录了来自480个样本的1270个eccDNA及相关基因注释。该数据库整合了多组学信息，便于研究eccDNA在癌症中的生物功能和临床意义。