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VINCULIN: A Crucial Hub Gene in Enteric Nervous System Development and Its Implications in Hirschsprung Disease

NIAID Data Ecosystem2026-05-10 收录

肠道神经发育

先天性巨结肠病基因研究

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP602849 数据链接链接失效反馈

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资源简介：

This study explored the role of Vcl gene in enteric nervous system development using high-resolution sequencing data from embryonic mouse guts at E13.5 and E15.5.

应用场景：

创建时间：

2025-11-13

肠道神经发育

基因通路分析

List of the canonical pathways in the two intestinal cell populations. Pathway analysis on the genes enriched in both the populations to identify the most significant pathways. The analysis was accomp

NIAID Data Ecosystem150

Emergence of neurons in enteric neurosphere culture

肠道神经发育

胶质细胞分化

These images were taken to test the hypothesis that glial cells isolated from the myenteric ganglia of the enteric nervous system can differentiate into neurons. Cells from the LMMP layer of Baf53b::C

Mendeley Data30

RNA Seq analysis of E9.5 embryonic vagal regions in Rdh10 mutants of mouse

Hirschsprung病发病机制

肠道神经发育

The enteric nervous system (ENS) is formed from vagal neural crest cells (NCC), which generate the neurons and glia that regulate gastrointestinal function. Defects in the migration, colonization or d

Alliance of Genome Resources10

Single Cell RNA-sequencing analysis of the juvenile and postnatal mouse enteric nervous system of the small intestine. Single Cell RNA-sequencing analysis of the juvenile and postnatal mouse enteric nervous system of the small intestine

单细胞转录组学

肠道神经发育

The study aimed to achieve a molecular definition of submucosal neuron classes in the mouse small intestine and describe their differentiation from enteric stem cells during postnatal stages. Method:

NIAID Data Ecosystem60

Single-cell transcriptomic and epigenetic profiling of mouse myenteric plexus glial cells

单细胞神经胶质组学

肠道神经发育

This study was undertaken to define the molecular subtypes of myenteric plexus glial cells in mice, and to understand the molecular basis for glial cells’ capacity to become neurons. Methods: We perfo

NIAID Data Ecosystem30

VINCULIN: A Crucial Hub Gene in Enteric Nervous System Development and Its Implications in Hirschsprung Disease

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