RXRs are required for neonatal expansion of the serosal macrophage pool and contribute to ovarian cancer progression

Distinct macrophage populations throughout the body display highly heterogeneous transcriptional and epigenetic programs. However, the regulation of chromatin accessibility of tissue-resident macrophages is poorly understood. In this study, we generated a data set for genome-wide transposase-accessible chromatin analysis (ATAC-seq) of large peritoneal macrophages in animals with myeloid-specific double deletion of the nuclear receptors RXRa and RXRb. Overall design: The chromatin accessibility profiles of sorted large peritoneal macrophages (LPMs) from 9-week-old wild type (WT) and RXRa/RXRb-deficient (KO) mice were generated by deep sequencing in duplicate using 2×50 HiSeq 3000 (Illumina) and with an average of 25 million paired-end reads per sample.