Epithelial cells provide an initial line of defense against damage and pathogens in barrier tissues such as the skin; however this balance is disrupted in obesity and metabolic disease. Skin gamma de
Members of the Interferon Regulatory Factor (IRF) family of transcription factors play an essential role in the development and function of the immune system. Here we investigated the role of IRF7 in
TRIM28 is a nuclear protein that is crucial for gene silencing through heterochromatin formation and maintenance. A genetic loss of TRIM28 in mouse dendritic cells, a professional antigen presenting c
