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Effect of FOSL1 and HDAC2 knockdown on gene expression in cancer cell lines

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NIAID Data Ecosystem2026-05-02 收录
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We identifled FOSL1 and HDAC2 as master regulators of cancer cell metabolism. To validate their function, we knockdown FOSL1 in pancreatic adenocarcinoma cell line PANC-1 and HDAC2 in lung adenocarcinoma cell line H1299, respectively. Then RNA-seq was performed to investigate the alterations of metabolic genes. Comparative gene expression profiling analysis of RNA-seq data for knockdown cell lines and controls. Three replicates were included for each group.

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2024-11-25
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