Enhancer infestation drives tumorigenic activation of inactive compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma

NIAID Data Ecosystem2026-05-01 收录

EB病毒阳性鼻咽癌

增强子激活机制

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE225251 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2024-03-28

PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation. PPARγ lipodystrophy mutants reveal intermolecular interactions required for enhancer activation

增强子激活机制

脂肪营养不良基因调控

In this setup we have used RNA-seq, ChIP-seq, and ATAC-seq to identify how natural mutations in PPARg, which leads to lipodystrophy, cause changes in transcription, chromatin landscape, transcription

NIAID Data Ecosystem50

PLZF targets developmental enhancers for activation during osteogenic differentiation of human mesenchymal stem cells (RNA-seq)

成骨分化基因调控

增强子激活机制

The PLZF transcription factor is essential for osteogenic differentiation of hMSCs, however, its regulation and molecular function during this process is not fully understood. Here we revealed that th

NIAID Data Ecosystem20

A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer [GRO-seq]. A non-canonical role of YAP/TEAD is required for activation of estrogen-regulated enhancers in breast cancer [GRO-seq]

癌症转录调控

增强子激活机制

Estrogen and estrogen receptor alpha (ERα) signaling plays an essential role in ERα-positive breast cancer. ERα mainly occupies on distal enhancers within genome and requires the cooperation of additi

NIAID Data Ecosystem10

JMJD6 licenses estrogen receptor alpha-dependent enhancer RNA and coding gene activation by modulating CARM1/MED12 co-activator complex in breast cancer [Gro-Seq]

激素受体阳性乳腺癌

增强子激活机制

Enhancers are genomic regulatory elements shown to play key roles in controlling cell type-specific gene expression, regulated by signal-dependent transcription factors and co-factors. Distinct classe

NIAID Data Ecosystem30

Enhancer Activation Requires Trans-Recruitment of a Mega Transcription Factor Complex (ChIP-seq). Homo sapiens

增强子激活机制

MegaTrans复合物招募

Enhancers provide critical information directing cell-type specific transcriptional programs, regulated by binding of signal-dependent transcription factors and their associated cofactors. Here we rep

NIAID Data Ecosystem20

Enhancer infestation drives tumorigenic activation of inactive compartment in Epstein-Barr virus-positive nasopharyngeal carcinoma

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