Baseline characteristics of the sub-cohort according to genotype, and clinical characteristics of CHD cases and controls in the Prospect –Epic cohort.

HDL, high-density lipoprotein; LDL, low-density lipoprotein; CHD, coronary heart disease (ICD 410–414). aMean±standard deviation. bComparison of risk factors across genotypes, using the ANOVA F test (continuous variables) and the χ2 statistic (categorical variables). cComparison of risk factors across disease status, using the independent samples t-test (continuous variables) and the χ2 statistic (categorical variables). dDefined as a systolic blood pressure ≥140 mm Hg and/or diastolic blood pressure ≥90 mm Hg and/or questionnaire positive. eThe number of packs of cigarettes smoked per day by the number of years the person has smoked.