This study explores the role of FTO-mediated m6A RNA methylation in ovarian cancer progression. Bioinformatics and clinical analyses revealed significant FTO downregulation in tumor tissues, correlati

Figshare2025-03-07 更新50

A unified model for the function of YTHDF proteins in the regulation of m6A-modified mRNA

m6A甲基化调控

YTHDF蛋白功能

N6-methyladenosine (m6A) is the most abundant mRNA nucleotide modification and regulates critical aspects of cellular physiology and differentiation. m6A is thought to mediate its effects through a co

NIAID Data Ecosystem30

Pooled CRISPR Screening Identifies m6A as a Positive Regulator of Macrophage Activation [RNA-seq]

m6A甲基化调控

巨噬细胞免疫

The involvement of m6A modification in macrophage activation has been validated in our study that the expression of TNF-a in Mettl3-depleted Raw 264.7 cells stimulated with LPS were markedly reduced i

NIAID Data Ecosystem70

Next Generation Sequencing Facilitates Quantitative Analysis of mRNA lifetime of Wild Type and Mettl3-/- mice

m6A甲基化调控

树突状细胞RNA稳定性

Considering m6A modification in mRNA was reported to be intensively correlated with RNA decay, for example, T cells and neurone cells. We wondered whether deleting Mettl3, the main catalzing enzyme, a

NIAID Data Ecosystem30

Long noncoding RNA lnc-H2AFV-1 promotes cell growth by regulating aberrant N6-methyladenosine RNA modification in HNSCC

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