The concentration of each drug was determined according to which it is administered in clinical practice. SD: Standard Deviation calculated from three independent repeats (n = 3). Selectivity: Drugs c
AUCinf, area under the concentration-time curve extrapolated to infinity; CM, cisterna magna; CSF, cerebrospinal fluid; EF, exposure fraction; F, bioavailability; I2S, iduronate-2-sulfatase; IT-L, int
Results expressed as mean ± standard deviation of three animals.aBoth compounds were delivered ip at 3 mg/kg with samples obtained 90 min after dosing.bConcentrations expressed per g tissue.Plasma and
