Inflammation-mediated oncogenesis has been implicated in a variety of cancer types. Rheumatoid synovial tissues can be viewed as a tumor-like mass, consisting of hyperplastic fibroblast-like synoviocy
Inflammatory tissues are characterized by low oxigen concentrations (hypoxia). These conditions are very different from that usually present in tissue cultures where transcriptomic profiles of human f
Comparison between early passage to later passages of rheumatoid arthritis synovial fibroblast (RASF) populations using two different AtlasTM Human Arrays Gene expression changes during culture with i
We demonstrate that JQ1 inhibits IL1B based RA Synovial Fibroblast activation and proliferation, by inhibiting key BRD2/4 superenhancer genes. Overall design: FLS cells pre and post JQ1 treatment; ass
We demonstrate that JQ1 inhibits IL1B based RA Synovial Fibroblast activation and proliferation, by inhibiting key BRD2/4 superenhancer genes. FLS cells pre and post JQ1 treatment; associated ChIP-Seq
