Identification of endothelial derived factors that promote metastasis III
收藏NIAID Data Ecosystem2026-03-12 收录
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资源简介：
To identify endothelial-derived factors that may instructively drive cancer metastasis, we generated a new mouse model that allows endothelial-specific ribosomal tagging. We crossed the RiboTag (Rpl22fl/flHA) mice with the endothelial inducible Cre line Cdh5(PAC)-CreERT2 mice. Endothelial derived ribosome-associated mRNA-sequencing was performed from highly metastatic B16F10 and poorly metastatic B16F0 tumours. Overall design: Immunoprecipitation and RNASeq of RNA bound to monoclonal dsRNA-specific antibody J2 in highly versus poorly metastatic mouse tumour cell lines.
创建时间：
2021-05-13
