Crystal Structure of ligand ACBI3 in complex with KRAS G12D C118S GDP and pVHL:ElonginC:ElonginB complex

Crystal Structure of ligand ACBI3 in complex with KRAS G12D C118S GDP and pVHL:ElonginC:ElonginB complex Descriptor: (2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-azanyl-3-cyano-4-methyl-6,7-dihydro-5H-1-benzothiophen-4-yl]-1,2,4-oxadiazol-3-yl]pyrimidin-2-yl]-3-methyl-1,4-diazepan-1-yl]butoxy]-1,2,3-triazol-1-yl]-3-methyl-butanoyl]-N-[(1R)-1-[4-(4-methyl-1,3-thiazol-5-yl)phenyl]-2-oxidanyl-ethyl]-4-oxidanyl-pyrrolidine-2-carboxamide, Elongin-B, Elongin-C, ... Authors: Wijaya, A.J, Zollman, D, Farnaby, W, Ciulli, A. Deposit date: 2023-10-18 Release date: 2023-12-06 Last modified: 2024-10-02 Method: X-RAY DIFFRACTION (2.24 Å) Cite: Targeting cancer with small-molecule pan-KRAS degraders. Science, 385, 2024配体ACBI3与KRAS G12D C118S GDP以及pVHL（希佩尔-林道蛋白）:ElonginC（延伸蛋白C）:ElonginB（延伸蛋白B）复合物结合的晶体结构 描述符：(2S,4R)-1-[(2S)-2-[4-[4-[(3S)-4-[4-[5-[(4S)-2-氨基-3-氰基-4-甲基-6,7-二氢-5H-1-苯并噻吩-4-基]-1,2,4-恶二唑-3-基]嘧啶-2-基]-3-甲基-1,4-二氮杂环庚烷-1-基]丁氧基]-1,2,3-三唑-1-基]-3-甲基-丁酰基]-N-[(1R)-1-[4-(4-甲基-1,3-噻唑-5-基)苯基]-2-羟基-乙基]-4-羟基-吡咯烷-2-甲酰胺、延伸蛋白B、延伸蛋白C…… 作者：Wijaya, A.J、Zollman, D、Farnaby, W、Ciulli, A 存档日期：2023-10-18 发布日期：2023-12-06 最后更新日期：2024-10-02 实验方法：X射线衍射（2.24 Å） 引用文献：《靶向癌症的小分子泛KRAS降解剂》，《科学》, 385, 2024