DARTS coupled MS analysis to identify the potential directed proteins targets of pyrroloquinoline quinone (PQQ)

The aim of this study is to identify the potential directed protein targets of PQQ, the natural phytochemical agent with antioxidant, anti-inflammatory and anticancer properties reported by former studies, on human primary stromal cells induced senescent in vitro by a genotoxic agent frequently used in clinical oncology. The approach used in the present study is drug affinity responsive targets ability (DARTS) coupled MS analysis.