METTL3 Facilitates Hypertrophic Scar Fibrosis by Promoting pri-miRNA-31 Maturation and ZBTB20 Silencing in m6A-dependent Manner

NIAID Data Ecosystem2026-05-02 收录

肥厚性瘢痕纤维化

m6A表观转录组学

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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE246979 数据链接链接失效反馈

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This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

创建时间：

2024-08-30

Distinct N6-methyladenosine (m6A) Regulation of Innate Immune Responses During Bacterial Infections II. Distinct N6-methyladenosine (m6A) Regulation of Innate Immune Responses During Bacterial Infections II

m6A表观转录组学

感染免疫调控

N6-methyladenosine (m6A) is a dynamic post-transcriptional RNA modification influencing all aspects of mRNA biology. Here, we examined cellular m6A epitranscriptomes during P.aeruginosa infection to i

NIAID Data Ecosystem80

A novel RNA m6A modulator Zc3h13 plays an anchor role in facilitating nuclear RNA methylation and mouse embryonic stem cell self-renewal

m6A表观转录组学

胚胎干细胞自我更新

N6-methyladenosine (m6A) is an abundant modification in eukaryotic mRNA, regulating mRNA dynamics by influencing mRNA stability, splicing, export and translation. Recent studies discovered m6A methylt

NIAID Data Ecosystem20

m6A modification maps of mRNA in bone marrow-derived macrophages (BMDMs) from mouse. m6A modification maps of mRNA in bone marrow-derived macrophages (BMDMs) from mouse

m6A表观转录组学

巨噬细胞免疫调节

We report the application of sequencing technology for high-throughput profiling of mRNA m6A methylation in mice BMDMs with or without PBS treatment. By obtaining over thirty billion bases of sequence

NIAID Data Ecosystem20

A study of m6A modification controls the innate immune response to infection by targeting type I interferons

m6A表观转录组学

先天免疫调控

Full immunoblots images for cropped gels which appear in the paper.

NIAID Data Ecosystem70

The m6A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis [m6A-RIP-seq]. The m6A methyltransferase Mettl3 deficiency attenuates hepatic stellate cell activation and liver fibrosis [m6A-RIP-seq]

肝纤维化

m6A表观转录组学

m6A-RIP sequencing of primary hepatic stellate cells (HSCs) isolated from Control and HSC-specific Mettl3-knockout (Mettl3 cKO) mouse liver tissues. Overall design: Control and Mettl3 cKO mouse primar

NIAID Data Ecosystem20

METTL3 Facilitates Hypertrophic Scar Fibrosis by Promoting pri-miRNA-31 Maturation and ZBTB20 Silencing in m6A-dependent Manner

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