Data from: <b>Genetically predicted </b><b>brain cortical structure </b><b>mediate the </b><b>causality</b><b> between </b><b>insulin resistance</b><b> and </b><b>cogniti</b><b>ve impairment</b>

Supplemental material for "Genetically predicted brain cortical structure mediate the causality between insulin resistance and cognitive impairment". Insulin resistance is tightly related to cognition; however, the causal association between them remains a matter of debate. Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brain cortical structure in this association. Our study noticed that elevated levels of insulin resistance adversely affected cognition, with a partial mediation effect through alterations in brain cortical structure.