Data from: <b>Genetically predicted </b><b>brain cortical structure </b><b>mediate the </b><b>causality</b><b> between </b><b>insulin resistance</b><b> and </b><b>cogniti</b><b>ve impairment</b>

Supplemental material for "Genetically predicted brain cortical structure mediate the causality between insulin resistance and cognitive impairment". Insulin resistance is tightly related to cognition; however, the causal association between them remains a matter of debate. Our investigation aims to establish the causal relationship and direction between insulin resistance and cognition, while also quantifying the mediating role of brain cortical structure in this association. Our study noticed that elevated levels of insulin resistance adversely affected cognition, with a partial mediation effect through alterations in brain cortical structure.

《遗传预测的大脑皮层结构（brain cortical structure）介导胰岛素抵抗（insulin resistance）与认知损害（cognitive impairment）间的因果关系》补充材料。胰岛素抵抗与认知功能密切相关，但二者间的因果关联仍存在争议。本研究旨在明确胰岛素抵抗与认知功能间的因果关系及作用方向，并量化大脑皮层结构在该关联中的中介作用。本研究发现，胰岛素抵抗水平升高会对认知功能产生不良影响，且该效应可通过大脑皮层结构改变产生部分中介效应。