Cu(OAc)<sub>2</sub>‑Promoted Ortho C(sp<sup>2</sup>)–H Amidation of 8‑Aminoquinoline Benzamide with Acyl Azide: Selective Formation of Aroyl or Acetyl Amide Based on Catalyst Loading
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An efficient method for the C(sp2) amidation of 8-aminoquinoline benzamide by acyl azide in the presence of copper acetate has been achieved via C–H activation. Interestingly, the loading of copper acetate has a strong influence on the outcome of the reaction. The use of 1 equiv of copper acetate produces the corresponding aroyl amide, whereas the use of 2 equiv led to acetyl amide. A series of substituted benzoyl and acetyl amides has been obtained.
创建时间：
2018-09-20
