Oscillatory cAMP Signaling Rapidly Alters H3K4 Methylation

Alliance of Genome Resources2026-08-01 收录

H3K4甲基化

cAMP信号转导

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https://www.ncbi.nlm.nih.gov/gds/?term=GSE125728 数据链接链接失效反馈

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In this study we show that cAMP affects gene expression by altering H3K4me3 marks. Note, "Control" samples are untreated with cAMP.

Model parameters.

cAMP信号转导

动力学参数估计

Adenylyl cyclase (AC) and phosphodiesterase (PDE) activities were estimated from published rates of cAMP production or hydrolysis (pmol/mg/min), respectively, assuming HEK293 cell volume of 2.5 pL [11

NIAID Data Ecosystem50

cAMP stimulation of acetylcholine receptor expression is mediated through posttranslational mechanisms.

胆碱能受体调控

cAMP信号转导

When the four Torpedo acetylcholine receptor (AcChoR) subunit cDNAs are stably integrated into the genome of mouse fibroblast cells, alpha 2 beta gamma delta pentamers with proper pharmacological and

PubMed Central1991-02-01 更新30

Structural Analyses of a Constitutively Active Mutant of Exchange Protein Directly Activated by cAMP

cAMP信号转导

构象动力学

Exchange proteins directly activated by cAMP (EPACs) are important allosteric regulators of cAMP-mediated signal transduction pathways. To understand the molecular mechanism of EPAC activation, we hav

NIAID Data Ecosystem30

Effect of PDE inhibition on basal submembrane cAMP signal in RASMCs.

cAMP信号转导

PDE抑制效应

Submembrane cAMP measurements were conducted in cultured RASMCs cells using the FRET-based cAMP sensor pm-Epac2-camps. The % increase in CFP/YFP ratio induced by the different PDE inhibitors or the ve

NIAID Data Ecosystem40

RNA-Seq of delta-cyaA E.coli mutant at 10 different cAMP concentration. RNA-Seq of delta-cyaA E.coli mutant at 10 different cAMP concentration

细菌转录组学

cAMP信号转导

Most research involved in studying the response of gene expression to cAMP have done so under binary states, that is, presence and absence of cAMP in the cell. However, cAMP concentrations in the cell

NIAID Data Ecosystem30

Oscillatory cAMP Signaling Rapidly Alters H3K4 Methylation

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