Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ADO_AC_093)

Crystal structure of the human METTL3-METTL14 complex bound to Compound 8 (ADO_AC_093) Descriptor: 4-[6-[(4,4-dimethylpiperidin-1-yl)methyl]pyridin-3-yl]-9-[6-[(phenylmethyl)amino]pyrimidin-4-yl]-1,4,9-triazaspiro[5.5]undecan-2-one, ACETATE ION, N6-adenosine-methyltransferase catalytic subunit, ... Authors: Bedi, R.K, Dolbois, A, Caflisch, A. Deposit date: 2021-03-26 Release date: 2021-09-01 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (1.9 Å) Cite: 1,4,9-Triazaspiro[5.5]undecan-2-one Derivatives as Potent and Selective METTL3 Inhibitors. J.Med.Chem., 64, 2021结合化合物8（ADO_AC_093）的人类METTL3-METTL14复合物的晶体结构 描述符：4-[6-[(4,4-二甲基哌啶-1-基)甲基]吡啶-3-基]-9-[6-[(苄基)氨基]嘧啶-4-基]-1,4,9-三氮杂螺[5.5]十一烷-2-酮、乙酸根离子、N6-腺苷甲基转移酶催化亚基…… 作者：Bedi, R.K.、Dolbois, A.、Caflisch, A. 提交日期：2021-03-26 发布日期：2021-09-01 最后修改日期：2024-10-23 实验方法：X射线衍射（分辨率1.9 Å） 引用文献：《1,4,9-三氮杂螺[5.5]十一烷-2-酮衍生物作为强效选择性METTL3抑制剂》，《药物化学杂志（J.Med.Chem.）》，2021年，第64卷