One-Pot Synthesis of 3‑Substituted 2‑Arylpyrrole in Aqueous Media via Addition–Annulation of Arylboronic Acid and Substituted Aliphatic Nitriles
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Pd(II)-catalyzed C–C coupling reactions between substituted aliphatic nitriles and arylboronic acids followed by in situ cyclodehydration have been employed for the first time to synthesize a wide variety of 3-substituted 2-aryl-1H-pyrroles in aqueous acetic acid. This one-pot synthesis is green, and it conforms to atom economy. The structures of two representative pyrroles, 3k and 5f, were confirmed by X-ray crystallographic analysis.
创建时间：
2017-04-10
