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Synthesis of Polysubstituted Pyrazoles by a Platinum-Catalyzed Sigmatropic Rearrangement/Cyclization Cascade

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NIAID Data Ecosystem2026-03-09 收录
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A highly efficient Pt-catalyzed [3,3] sigmatropic rearrangement/cyclization cascade of N-propargyl­hydra­zones is reported. The process provides expedient access to a variety of highly functionalized pyrazoles. The substrate has good substituted group compatibility, and the bioactive 3-CF3 pyrazoles could be synthesized easily with this method.

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2014-11-21
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