Mettl3-mediated m6A modification controls postnatal liver development by modulating Hnf4a-centred regulatory network [Liver RNA-seq]

RNA sequencing of livers tissues from control and hepatocyte-specific Mettl3 knockout with ALB-Cre (Mettl3 cKO) mice at different time points after birth. Control and Mettl3 cKO mouse liver tissues were collected separately at day 1, 1 week, 2 weeks, and 4 weeks after birth. Differentially expressed genes and related pathways were analyzed and compared between Control and Mettl3 cKO livers to show how Mettl3 affects postnatal liver development.本数据集针对经ALB-Cre介导的肝细胞特异性Mettl3敲除（Mettl3 cKO）小鼠与对照组小鼠在出生后不同时间点的肝脏组织开展RNA测序（RNA sequencing）。分别于出生后第1天、1周、2周及4周采集两组小鼠的肝脏组织；通过分析并对比对照组与Mettl3 cKO小鼠肝脏的差异表达基因（differentially expressed genes）及相关通路，揭示Mettl3对出生后肝脏发育的调控作用。