Asymmetric Hydrogenation via Capture of Active Intermediates Generated from Aza-Pinacol Rearrangement
收藏NIAID Data Ecosystem2026-03-09 收录
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An efficient palladium-catalyzed asymmetric hydrogenation via capture of an active intermediate generated in situ from acid-catalyzed aza-Pinacol rearrangement has been successfully developed, providing efficient access to chiral exocyclic amines with up to 98% ee. Three-, four-, and five-membered cyclic N-sulfonyl amino alcohols are viable substrates. This study opens a new window to the application of asymmetric hydrogenation.
创建时间：
2016-02-16
