Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac)

Crystal Structure of the first bromodomain of human BRD4 in complex with a diacetylated histone 4 peptide (H3K9ac/K14ac) Descriptor: Bromodomain-containing protein 4, Histone H3 Authors: Filippakopoulos, P, Picaud, S, Pike, A.C.W, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C. Deposit date: 2017-04-08 Release date: 2018-05-16 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2.22 Å) Cite: Interactome Rewiring Following Pharmacological Targeting of BET Bromodomains. Mol. Cell, 73, 2019人BRD4首个溴结构域（bromodomain）与双乙酰化组蛋白H4肽（H3K9ac/K14ac）复合物的晶体结构 描述：含溴结构域蛋白4、组蛋白H3 作者：Filippakopoulos, P、Picaud, S、Pike, A.C.W、von Delft, F、Arrowsmith, C.H、Edwards, A.M、Bountra, C. 提交日期：2017-04-08 发布日期：2018-05-16 最后修改日期：2024-10-16 实验方法：X射线衍射（2.22 埃） 引用文献：《靶向BET溴结构域的药理学干预后的相互作用组重编程》，《分子细胞》（Mol. Cell），第73卷，2019年