One-Pot Multicatalytic Approaches for the Synthesis of Cyclohepta[<i>b</i>]indoles, Indolotropones, and Tetrahydrocarbazoles

Diversity oriented one-pot synthesis of cyclohepta­[b]­indoles, indolotropones, and tetrahydrocarbazoles (THCs) have been reported. Readily accessible 3-(2-aminophenyl)-5-hexenyn-3-ols under a one-pot trimetallic orthogonal catalysis furnish tetrahydrocyclohepta­[b]­indoles, and a one-pot quadruple reaction sequence of the enynols generates dihydrocyclohepta­[b]­indoles and indolotropones. During this study, formation of THCs was realized to be a reason for the yield loss in certain cases, this observation led to the development of a one-pot bimetallic approach for the synthesis of 1,3-disubstituted THCs.