RNA sequencing of control and dystrophin-mutant engineered heart tissues from human induced pluripotent stem cell-derived cardiomyocytes. RNA sequencing of control and dystrophin-mutant engineered heart tissues from human induced pluripotent stem cell-derived cardiomyocytes

We report the transcriptomic differences between engineered heart tissues generated from hiPSCs with a dystrophin-truncating mutation and an isogenic control. We find that the dystrophin mutation induces profound differences at the transcriptomic level and illuminates potential disease-causing mechanisms. Overall design: RNA sequencing of control and dystrophic engineered heart tissues