Data from: Calling in sick: impacts of fever on intra-urban human mobility

Pathogens inflict a wide variety of disease manifestations on their hosts, yet the impacts of disease on the behaviour of infected hosts are rarely studied empirically and are seldom accounted for in mathematical models of transmission dynamics. We explored the potential impacts of one of the most common disease manifestations, fever, on a key determinant of pathogen transmission, host mobility, in residents of the Amazonian city of Iquitos, Peru. We did so by comparing two groups of febrile individuals (dengue-positive and dengue-negative) with an afebrile control group. A retrospective, semi-structured interview allowed us to quantify multiple aspects of mobility during the two-week period preceding each interview. We fitted nested models of each aspect of mobility to data from interviews and compared models using likelihood ratio tests to determine whether there were statistically distinguishable differences in mobility attributable to fever or its aetiology. Compared with afebrile individuals, febrile study participants spent more time at home, visited fewer locations, and, in some cases, visited locations closer to home and spent less time at certain types of locations. These multifaceted impacts are consistent with the possibility that disease-mediated changes in host mobility generate dynamic and complex changes in host contact network structure.病原体（Pathogens）可使宿主出现多种多样的疾病表现（disease manifestations），但疾病对感染宿主行为的影响，鲜有实证研究，且在传播动力学（transmission dynamics）的数学模型中也极少被纳入考量范畴。我们以秘鲁亚马孙城市伊基托斯的居民为研究对象，探究最为常见的疾病表现之一——发热（fever），对病原体传播的关键决定因素——宿主移动性（host mobility）的潜在影响。本次研究通过将两组发热个体（登革热阳性与登革热阴性）与无热对照组（afebrile control group）进行对比展开。借助回顾性半结构化访谈（retrospective semi-structured interview），我们可量化每次访谈前两周内宿主移动性的多个维度。我们针对移动性的各维度构建嵌套模型，并结合访谈数据进行拟合，再通过似然比检验（likelihood ratio tests）对模型进行比较，以此明确发热或其病因学（aetiology）是否会导致宿主移动性出现统计学上可区分的差异。相较于无热个体，发热的研究受试者居家时长更长，到访地点更少；在部分场景中，他们到访的地点距离自家更近，且在特定类型场所的停留时长更短。上述多维度影响表明，疾病介导的宿主移动性变化，可能会使宿主接触网络结构（contact network structure）产生动态且复杂的改变。