SUMOylation affects many aspects of target proteins such as activity, stability, localization and protein-protein interactions. We have found that SUMOylation of YTHDF2 increased its binding activity

NIAID Data Ecosystem60

Next Generation Sequencing Facilitates Quantitative Analysis of mRNA lifetime of Wild Type and Mettl3-/- mice

m6A甲基化调控

树突状细胞RNA稳定性

Considering m6A modification in mRNA was reported to be intensively correlated with RNA decay, for example, T cells and neurone cells. We wondered whether deleting Mettl3, the main catalzing enzyme, a

NIAID Data Ecosystem40

Mettl3/m6A promotes translation of pathogenic mRNAs to mediate cystogenesis in mouse models of ADPKD

m6A甲基化调控

多囊肾病囊肿形成

Purpose: Determine the differential m6A methylation pattern of Mettl3 between wildtype, Pkd1F/RC-KO and Pkd1F/RC-Mettl3-DKO mouse kidneys. Methods: m6A RNA IP using the Magna MeRIPâ¢ m6A Kit (EMD Mil

NIAID Data Ecosystem70

YTHDF2 mediates the mRNA degradation in prostate cancer in m6A-dependent way. YTHDF2 mediates the mRNA degradation in prostate cancer in m6A-dependent way

m6A甲基化调控

前列腺癌分子机制

As the crucial m6A reader, YTHDF2 usually degrades the target mRNAs by recognizing the m6A modified sites, consequently altering m6A levels of each mRNA. In this study, we used m6A MeRIP sequencing to

NIAID Data Ecosystem40

mRNA N6-Methyladenosine methylome of Brassica napus and its progenitors/parents.

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