Supplementary Tables (Mapping the Associations of the Plasma Lipidome With Insulin Resistance and Response to an Oral Glucose Tolerance Test)

Context: Insulin resistance (IR) remained a global health challenge. Lipidomics offers a unique opportunity to identify biomarkers; a key step towards understanding mechanisms of IR associated with abnormal lipid metabolism. Objective: To determine whether plasma lipid species are associated with indices of insulin resistance and to evaluate the plasma lipidome response to an OGTT. Design and Setting: Community based cross-sectional Participants and sample: Plasma samples (collected at 0 and 120 min during an OGTT) from non-obese, young adults aged between 18-34 years (n = 246) were analysed using liquid chromatography tandem mass spectrometry. Main outcome measures: Using linear models (controlling for age, sex, BMI, total cholesterol, HDL-cholesterol and triglycerides), the associations between indices of insulin resistance and individual lipid species or changes in lipid levels during an OGTT were tested. Results: Some (213) and (199) lipid species associate with HOM...研究背景：胰岛素抵抗（Insulin Resistance，IR）仍是全球性公共卫生挑战。脂质组学（Lipidomics）为识别生物标志物（Biomarkers）提供了独特契机，是解析与脂质代谢异常相关的胰岛素抵抗发病机制的关键步骤。 研究目的：明确血浆脂质组分是否与胰岛素抵抗指数存在关联，并评估血浆脂质组（Plasma Lipidome）对口服葡萄糖耐量试验（Oral Glucose Tolerance Test，OGTT）的应答反应。 研究设计与场景：基于社区的横断面研究。 研究对象与样本：对18~34岁非肥胖青年成人（n=246）在口服葡萄糖耐量试验0分钟及120分钟时采集的血浆样本，采用液相色谱串联质谱法（Liquid Chromatography Tandem Mass Spectrometry）进行分析。 主要结局指标：通过线性模型（校正年龄、性别、体质量指数（Body Mass Index，BMI）、总胆固醇、高密度脂蛋白胆固醇（HDL-cholesterol）及甘油三酯），检验胰岛素抵抗指数与单个脂质组分，或口服葡萄糖耐量试验期间脂质水平变化之间的关联。 研究结果：共计213种及199种脂质组分与HOM...