Enantioselective C–H Functionalization–Addition Sequence Delivers Densely Substituted 3‑Azabicyclo[3.1.0]hexanes
收藏NIAID Data Ecosystem2026-03-10 收录
数据链接：
官方服务：
资源简介：
An enantioselective C–H functionalization route to perfluoroalkyl-containing 3-azabicyclo[3.1.0]hexanes is disclosed. A modular and bench-stable diazaphospholane ligand enables highly enantioselective Pd(0)-catalyzed cyclopropane C–H functionalization using trifluoroacetimidoyl chlorides as electrophilic partners. In turn, the resulting cyclic ketimine products react smoothly with a broad variety of nucleophiles in one-pot processes enabling the rapid and modular construction of heavily substituted pyrrolidines.
创建时间：
2017-09-01
