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Copper(II)-Catalyzed Domino Synthesis of 4‑Benzenesulfonyl Isoxazoles from 2‑Nitro-1,3-enynes, Amines, and Sodium Benzenesulfinate

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A simple and effective method for the synthesis of fully substituted 4-benzenesulfonyl isoxazoles through a copper­(II)-catalyzed three-component reaction of 2-nitro-1,3-enynes, amines, and sodium benzenesulfinate is described. The reaction proceeds smoothly under mild conditions and provides the benzenesulfonyl isoxazoles with high chemoselectivity.

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2020-10-21
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