Genomic profiling of normal and regenerating liver in young and old mice
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Genomic profiling of normal and regenerating liver in young and old mice
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2015-12-31
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Maintenance of genome sequence integrity in long and short-lived rodent species.
DNA mutations in somatic cells have been implicated in the causation of aging, with longer-lived species having a higher capacity to maintain genome sequence integrity than shorter-lived species. In a
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Additional file 2: of Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics
Collated single cell mRNA expression data used in this study. (TXT 111 kb)
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THE BILIARY EPITHELIUM GIVES RISE TO LIVER PROGENITOR CELLS BUT MAKES A MINOR CONTRIBUTION TO HEPATOCYTE REGENERATION AFTER LIVER INJURY. Mus musculus
We previously showed that severe liver diseases are characterized by expansion of liver progenitor cells (LPC), which correlates with disease severity. However, the origin and role of LPC in liver phy
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Additional file 5: of Cellular network modeling and single cell gene expression analysis reveals novel hepatic stellate cell phenotypes controlling liver regeneration dynamics
Zip file containing the raw mRNA expression data generated from single cells used in this manuscript. Data were manually inspected for reactions with CT values above those for water (below the limit o
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Super-enhancer RNA seRNAHP promotes liver regeneration via upregulation of phosphoglycerate dehydrogenase and serine biosynthesis
A 70% partial hepatectomy (PHx) was performed on male super-enhancer Nacc1-SE (located near the Nacc1 gene) knockout mice to evaluate the contribution of Nacc1-SE to liver regeneration. In vitro, prim
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